Treatment of humerus fracture with wise-lock implants

Background: Humerus fracture is a common fracture in aging population mainly occurring due to fall, high energy trauma and sports injury. Locking plate treatment is showing good results in stabilization of the fracture. The purpose of this study is to showcase the surgical treatment and results by using Auxein locking implants for the treatment of proximal humeral fracture.Methods: Prospectively 13 patients were treated with ORIF treatment (6 males, 7 females with an average age of 43.6years). Fracture type is classified as per the Muller AO classification of fracture, 6 patients had type 11-A1 and 7 patients had type 11-A2. 1 patient were felt under American Society of Anesthesiologists grade 2 have mild systemic disease. Clinical outcomes were assessed at 1year follow-up with visual analogue scale score at 4 week, 16 week, 24 week and 1 year.Results: The follow-up of patients was taken at 4th, 16th, 24th and 1 year bearing good clinical results. 2 patients were encountered with pain, these were elderly patients of the age 58 and 62 and had a history of other medical commodities. One patient reported of less weigh bearing ability which was relieved with physiotherapy.Conclusions: Open reduction internal fixation treatment with Pheelos 3.5 mm wise lock proximal humerus plate showed good results with improved performance and negligible complications.

Clinical outcomes in the treatment of femoral fracture by using intramedullary femur nailing system

Background: Femoral fractures are frequently occurring fractures that are caused due to large force impaction. The purpose of this study was to clinically evaluate the outcomes of treating femoral fractures with the use of the intramedullary femoral nailing system.Methods: This retrospective clinical trial consists of 32 patients with femoral fracture and are treated by using an intramedullary femoral nailing system which consists of retrograde femoral nail, gamma nails, expert femoral nail, universal intramedullary cannulated femoral nails that are manufactured by Auxein medical Pvt. Ltd. Sonipat, Haryana, India. There were 32 patients from two different hospitals i.e., first hospital group consist of 15 patients (8 male and 7 female) with mean age of 32 years and the second hospital group consist of 17 patients (9 male and 8 female). The fracture categorization was done on the basis of AO Classification of fracture and physical fitness was categorized by American society of anaesthesiologists. VAS score and HHS was used as a criterion for assessing the clinical outcomes of the patients.Results: There were 32 patients to whom surgery was performed and follow up time was 1 month, 3 months, 6 months and 12 months. After the final follow up no patient in any group complaint about the complications or any hardware related problem, there were perfect bone union in every patient. Radiological outcomes also showed proper union at 6 months follow up.Conclusions: For femoral fractures, intramedullary femoral nail gives a better result with high union rate and post-operative composure

Clinical performance of intramedullary nailing system for tibia fractures: a retrospective study

Background: In this study, we aimed to investigate the performance of the intramedullary tibia nailing system while treating the tibia fracture fixation.Methods: In this retrospective study, studied the results of intramedullary tibia nail in treatment of tibia fracture. A total of 25 consecutive patients were included in this study (11 male, 14 female and average age 42.9 years). Fracture type was classified as per the Muller AO classification of fracture.Results: The outcomes of clinical treatment were obtained in our study; no pain (92%), mild pain (8%) after 2 year follow up. The follow up of patients were taken on 1 month, 6 months, 1 year and 2 years according to visual analog scale (VAS) score. Paired t test was performed for statistical data analysis using minitab and values of p<0.05 were taken to indicate significant value with confidence interval of 95%. No implant related problem have been found like loosening, bending and corrosion.Conclusions: Our outcomes with interlocking cannulated and expert tibial interlocking nailing are empowering and exhibit the advantages of new nailing framework. It has been concluded that intramedullary tibia nailing system is best method for treatment of tibia fracture with good results and outcomes

Clinical effectiveness of anterior cervical discectomy and fusion to treat cervical spondylosis using anterior cervical system

Background: Age related problems in the spinal segment bring about a degenerative course known as spondylosis. Hereditary, condition, and word related impacts may play a role. These spondylosis changes may bring about direct compressive and ischemic dysfunction of the spinal cord known as cervical spondylosis.Methods: In this examination 30 patients were selected with cervical spondylosis with, in the fundamental, myelography includes, and treated by anterior cervical discectomy and fusion using anterior cervical system (Apex plate) provided by Auxein Medical Pvt. Ltd. These patients are separated in two gatherings, one is male (12) and another female (18).  Functional outcome of the patients was assessed by the visual analogue scale score at post-operative follow up at 1months, 3 months, 6 months, 9 months and 1 year.Results: The after effects of this clinically treatment have by and large been great and this is especially so in old patients with an alternate injury, for example, C1-C2, C2-C3, C3-C4, C4-C5, C5-C6 and C6-C7.Conclusions: The finish of this examination is that the cervical spondylosis patients might be oversees effectively with anterior cervical discectomy and fusion utilizing anterior cervical system. Effectively clinical outcomes in regards to indications improvement and general fulfillment with the surgery were excellent with low rate of complications

Mitigation of acrylamide by l-asparaginase from Bacillus subtilis KDPS1 and analysis of degradation products by HPLC and HPTLC

The use of bacterial l-asparaginase (LA) is one of the alternative approaches for acrylamide reduction in food stuffs as it catalyzes the conversion of l-asparagine to l-aspartic acid and ammonia. In present investigation, purification of extracellular LA from isolate of Bacillus subtilis sp. strain KDPS-1 was carried out by solid state fermentation process. The effects of solid substrates, initial moisture content, moistening agents, temperature, and incubation time on LA production was studied, and the highest asparaginase activity (47 IU/ml) was achieved in the medium having orange peel as substrate. The enzyme was purified to homogeneity by diethylaminoethyl (DEAE) cellulose ion exchange chromatography; with 84.89 % yield and 12.11 fold purity. LA showed stimulant activity against β-mercaptoethanol and was greatly inhibited by Zn(2+) and Hg(2+) metal ions. Reduction of acrylamide in fried potatoes was detected by high performance liquid chromatography, which showed clear degradation of acrylamide by height and area (%) in the chromatograms of standard sample to that of the test sample. Hydrolysates analysis by high performance thin layer chromatography confirmed the test sample to be LA

Isolation and partial purification of erythromycin from alkaliphilic Streptomyces werraensis isolated from Rajkot, India

AbstractAn alkaliphilic actinomycete, BCI-1, was isolated from soil samples collected from Saurashtra University campus, Gujarat. Isolated strain was identified as Streptomyces werraensis based on morphological, biochemical and phylogenetic analysis. Maximum antibiotic production was obtained in media containing sucrose 2%, Yeast extract 1.5%, and NaCl 2.5% at pH 9.0 for 7 days at 30 °C. Maximum inhibitory compound was produced at pH 9 and at 30 °C. FTIR revealed imine, amine, alkane (CC) of aromatic ring and p-di substituted benzene, whereas HPLC analysis of partially purified compound and library search confirmed 95% peaks matches with erythromycin. Chloroform extracted isolated compound showed MIC values 1 μg/ml against Bacillus subtilis, ≤0.5 μg/ml against Staphylococcus aureus, ≤0.5 μg/ml against Escherichia coli and 2.0 μg/ml against Serretia GSD2 sp., which is more effective in comparison to ehtylacetate and methanol extracted compounds. The study holds significance as only few alkaliphilic actinomycetes have been explored for their antimicrobial potential

ANTIBACTERIAL ACTIVITY FROM HAEMOLYMPH OF FRESHWATER CRAB OF GENUS MAYDELLIATHELPHUSA AGAINST RESPIRATORY TRACT PATHOGENS

Objective: To study the antibacterial activity using haemolymph from a freshwater crab species of genus Maydelliathelphusa against respiratory tract pathogens.Methods: 3 ml of haemolymph was collected from the live animal with a fine sterile syringe and tested for antibacterial assay by the well diffusion method. Different quantities viz. 10μl, 20μl and 30μl of haemolymph were loaded in agar plates having bacterial strains and kept for incubation at 37 °C for 24 h to test the development of bacteria. Further, the efficacy of haemolymph against bacteria was compared with antibiotic erythromycin, used as positive control.Results: The results reported the strong inhibitory action of the haemolymph against the pathogens in the present study. The lowest zone of inhibition was observed against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) and the highest zone of inhibition was observed against Streptococcus pneumoniae (S. pneumoniae). Erythromycin, as a positive control and Di-Methyl Sulfoxide (DMSO), as a negative control were used to check the sensitivity of pathogens. The minimum inhibition concentration (MIC) of the haemolymph for the studied bacteria was ranged between 6.25 mg/ml and 12.5 mg/ml. Maximum inhibition % (151.12) and minimum inhibition % (12.87) of haemolymph was calculated for S. pneumoniae and K. pneumoniae respectively during the study.Conclusion: Study concluded that the haemolymph has a good antibacterial activity as it suppresses the growth of the bacteria completely at very low concentrations.Keywords: Freshwater Crab, Haemolymph, Antibacterial activity, Respiratory tract pathogens

A FRAMEWORK FOR P2P NETWORKING OF SMART DEVICES USING WI-FI DIRECT

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